| Synonym |
Complement Factor B; C3/C5 Convertase; Glycine-Rich Beta Glycoprotein; GBG; PBF2; Properdin Factor B; CFB; BF; BFD |
| Activity |
NA |
| Sequence |
Thr26-Leu764 |
| Fusion tag |
C-6His |
| Accession |
P00751 |
| Expressed Host |
Human cells |
| Shipping |
The product is shipped at ambient temperature.Upon receipt, store it immediately at the temperature listed below. |
| Purity |
＞95% as determined by reducing SDS-PAGE. |
| Endotoxin |
＜1.0 EU per µg as determined by LAL test. |
| Stability and Storage |
Store at < -20℃, stable for 6 monthshs after receipt.Please minimize freeze-thaw cycles |
| Mol Mass |
84.1 kDa |
| AP Mol Mass |
90 kDa |
| Formulation |
Supplied as a 0.2 μm filtered solution of 20mM TrisHCl, 150mM NaCl, pH 8.0. |
| Background |
Complement Factor B (CFB) belongs to the peptidase S1 family of enzymes. It is expressed by hepatocytes and macrophages and localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. CFB which is a component of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. |
| Description |
Aplha, transcription related growth factors and stimulating factors or repressing nuclear factors are complex subunits of proteins involved in cell differentiation. Complex subunit associated factors are involved in hybridoma growth, Eosinohils, eritroid proliferation and derived from promotor binding stimulating subunits on the DNA binding complex. NFKB 105 subunit for example is a polypetide gene enhancer of genes in B cells. |
| Properties |
Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples. |
| Source |
Recombinants or rec. proteins |
| Group |
recombinants |